USPTO Patents Application 09913800

JL

UOCKet NO.

RTSP-0155

Declaration and Power of Attorney For Patent Application

English Language Declaration

As a below named inventor, I hereby declare that:

My residence, post office address and citizenship are as stated below next to my name,

I believe I am the original, first and sole inventor (if only one name is listed below) or an original,

first and joint inventor (if plural names are listed below) of the subject matter which is claimed and for

which a patent is sought on the invention entitled

Antisense Modulation of AKT-2 Expression

the specification of which

(check one)

□ is attached hereto.

_| was filed on 5 October 1999 as United States Application No. or PCT International

Application Number PCT/US99/23169 ;

and was amended on .

(if applicable)

I hereby state that I have reviewed and understand the contents of the above identified specification,
including the claims, as amended by any amendment referred to above.

I acknowledge the duty to disclose to the United States Patent and Trademark Office all information
known to me to be material to patentability as defined in Title 37, Code of Federal Regulations,
Section 1.56.

I hereby claim foreign priority benefits under Title 35, United States Code, Section 119(a)-(d) or
Section 365(b) of any foreign application(s) for patent or inventor's certificate, or Section 365(a) of
any PCT International application which designated at least one country other than the United States,
listed below and have also identified below, by checking the box, any foreign application for patent or
inventor's certificate or PCT International application having a filing date before that of the application
on which priority is claimed.

Prior Foreign Application(s) Priority Not Claimed

□

(Number) (Country) (Day/Month/Year Filed)

- □

(Number) (Country) (Day/Month/Year Filed)

□

(Number) (Country) (Day/Month/Year Filed)

Form PTO-SB-01 (9-95) (Modified)

P02/REV02

Patent and Trademark Office-U.S. DEPARTMENT OF COMMERCE

; hereb" dcirri the benefit under 35 U.S.C. Section 1 1 Q'e^ of op." United States TGvisicp.c!

application(s) listed below:

(Application Serial No.)

(Filing Date) (

(Application Serial No.)

(Filing Date)

(Application Serial No.)

(Filing Date)

I hereby claim the benefit under 35 U. S. C. Section 120 of any United States application(s), or
Section 365(c) of any PCT International application designating the United States, listed below and,
insofar as the subject matter of each of the claims of this application is not disclosed in the prior
United States or PCT International application in the manner provided by the first paragraph of 35
U.S.C. Section 112, I acknowledge the duty to disclose to the United States Patent and Trademark
Office all information known to me to be material to patentability as defined in Title 37, C. F. R.,
Section 1 .56 which became available between the filing date of the prior application and the national
or PCT International filing date of this application:

09/256,465

February 23, 1999

Patented

(Application Serial No.)

(Filing Date)

(Status)

(patented, pending, abandoned)

(Application Serial No.)

(Filing Date)

(Status)

(patented, pending, abandoned)

(Application Serial No.) (Filing Date) (Status)

(patented, pending, abandoned)

I hereby declare that all statements made herein of my own knowledge are true and that all
statements made on information and belief are believed to be true; and further that these statements
were made with the knowledge that willful false statements and the like so made are punishable by
fine or imprisonment, or both, under Section 1001 of Title 18 of the United States Code and that such
willful false statements may jeopardize the validity of the application or any patent issued thereon.

Form PTO-SB-01 (6-95) (Modified)

Patent and Trademark Offlce-U.S. DEPARTMENT OF COMMERCE

POWER OF ATTORNEY: As a named inventor, I hereby appoint the following attorney(s) and/or
agent(s) to prosecute this application and transact all business in the Patent and Trademark Office
connected therewith, (list name and registration number) ,

Herb Boswell, Reg. N . 27,311
Laurel Spear Bernstein, Reg. No. 37,280
Robert S. Andrews, Reg. No. 44,508
April Logan, Reg. No. 33,950
Neil S. Bartfeld, Reg. No. 39,901
Kenneth H. Tarbet, Reg. No. 43,181
Donna T. Ward, Reg. No. P48,271
26259 of the firm

patent trademark office ISIS Pharmaceuticals, Inc.-Carlsbad Research Center

2292 Faraday Avenue
Carlsbad, California 92008

Send Correspondence to:

Direct Telephone Calls to: (name and telephone number)
Jane Massey Licata or Kathleen A. Tyrrell - (856) 810-1515

Full name of sole or first inventor

Brett P. Monia

Sole or first inventor's signature

Date

Residence

Encinitas, California

Citizenship

US

Post Office Address

2306 Casa Hermosa Court

Encinitas, California 92024

Full name of second inventor, if any
Lex M. Cowsert

Second inventor's signature Date

Residence

San Mateo, California

Citizenship
US

Post Office Address
1299 Parrott Drive

San Mate , California 94402

Form PTO-SB-01 (6-95) (Modified)

Patent and Trademark Office-U.S. DEPARTMENT OF COMMERCE